Ammonia → HCID 70357192、化合物
反応式
O=[C:2]([CH3:21])[CH2:3][C:4]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[C:12]1[CH3:20])=[O:5].[NH3:22]>C(O)C>[NH2:22][C:2]([CH3:21])=[CH:3][C:4]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[C:12]1[CH3:20])=[O:5]参加物
4
実験手順
4-(2-Methylimidazo[4,5-c]pyrid-1-yl)butyl 3-oxobutanoate (1.52 g) (see Preparation 6) was dissolved in ethanol (50 ml) containing dry silica gel (2.5 g) and gaseous ammonia was then bubbled through the mixture for 20 minutes. The mixture was stirred at room temperature for a further 11/2 hours and then filtered and evaporated to dryness leaving the crude title compound (1.54 g) which was used directly.
後処理
- customwas then bubbled through the mixture for 20 minutes
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-3e6647fa7e4b4c9a8695c736c26935c1
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04904671
反応ノート
読み込み中…