関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 3-Bromopyridine | HCID 12286 | — |
| 試薬 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | P-Xylene | HCID 7809 | — |
| 生成物 | 1-(Pyridin-3-yl)piperazine | HCID 437234 | 0% |
反応手順
In a 100 ml RBF, 3-bromopyridine (1.220 mL, 12.66 mmol) was taken in xylenes (20 mL). To this was added tris(dibenzylideneacetone)dipalladium(0) (0.232 g, 0.25 mmol), tri-t-butylphosphine (10%wt in Hexane) (1.281 g, 0.63 mmol) and sodium tert-butoxide (1.825 g, 18.99 mmol). Then piperazine (6.54 g, 75.95 mmol) was added to RM and the RM was then heated at 130 °C for 5 hrs. The reaction was monitored by LCMS. It did not show formation of product. The RM was discarded.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-5ee406d12bbe4c6fbfb323cf21dcbb47 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
