Hydrochloric Acid → Methyl 5-chloro-3-hydroxythiophene-2-carboxylate
反応式
Cl[C:2]1([C:8]([O:10][CH3:11])=[O:9])[C:6](=[O:7])[CH:5]=[CH:4][S:3]1.[ClH:12]>C(O)(=O)C>[Cl:12][C:4]1[S:3][C:2]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([OH:7])[CH:5]=1参加物
4
実験手順
A solution of 2-chloro-2-methoxycarbonylthiophene-3(2H)-one (30 mmol) in acetic acid (20 ml) was saturated with dry hydrogen chloride gas. After standing for 3 days the solvent was removed under reduced pressure and the oily residue distilled to give a yellow liquid which crystallised on addition of aqueous acetic acid (m.p. 42°-44° C.).
後処理
- customthe solvent was removed under reduced pressure
- distillationthe oily residue distilled
- customto give a yellow liquid which
- customcrystallised on addition of aqueous acetic acid (m.p. 42°-44° C.)
出典と根拠
- ORDレコード
- ord-54ac88c49b634371b5a37340dd9d777a
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04904686
反応ノート
読み込み中…