HCID 15588103、化合物 → Methyl 4-chloro-3-hydroxythiophene-2-carboxylate
反応式
Cl[C:2]1([C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:7])[C:5]([Cl:8])=[CH:4][S:3]1>C(O)(=O)C.[Zn]>[Cl:8][C:5]1[C:6]([OH:7])=[C:2]([C:9]([O:11][CH3:12])=[O:10])[S:3][CH:4]=1参加物
4
実験手順
2,4-Dichloro-2-methoxycarbonylthiophene-3(2H)-one (60 mmol) in acetic acid (50 ml) was treated with metallic zinc (60 mmol) at room temperature for 18 hours. The solvent was removed under reduced pressure and the residue partitioned between water and ether. The organic phase was washed with water, dried with sodium sulphate and the solvent removed under reduced pressure to leave a solid which was crystallised from hexane m.p. 76°-77° C.
後処理
- customThe solvent was removed under reduced pressure
- customthe residue partitioned between water and ether
- washThe organic phase was washed with water
- dry with materialdried with sodium sulphate
- customthe solvent removed under reduced pressure
- customto leave a solid which
- customwas crystallised from hexane m.p. 76°-77° C.
出典と根拠
- ORDレコード
- ord-90b2f277360440e4b238740d48925f0d
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04904686
反応ノート
読み込み中…