Hydrochloric Acid → Methyl 4,5-dichloro-3-hydroxythiophene-2-carboxylate
反応式
[ClH:1].Cl[C:3]1([C:10]([O:12][CH3:13])=[O:11])[C:7](=[O:8])[C:6]([Cl:9])=[CH:5][S:4]1>C(O)(=O)C>[Cl:9][C:6]1[C:7]([OH:8])=[C:3]([C:10]([O:12][CH3:13])=[O:11])[S:4][C:5]=1[Cl:1]参加物
4
実験手順
Dry hydrogen chloride gas was bubbled into a solution of crude 2,4-dichloro-2-methoxycarbonylthiophen-3(2H)-one (6.8 g, 30 mmol) in acetic acid (30 ml) until saturated. The mixture was allowed to stand for 2 days, concentrated under reduced pressure and the precipitate filtered and recrystallised from methanol, m.p. 107°-108° C.
後処理
- concentrationconcentrated under reduced pressure
- filtrationthe precipitate filtered
- customrecrystallised from methanol, m.p. 107°-108° C.
出典と根拠
- ORDレコード
- ord-1274e401e5b042918c0038b03a56a2a9
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04904686
反応ノート
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