Ethanol → HCID 14650456、化合物

HRID 1200188ノート

反応式

HRID 1200188 の反応式
[C:1]1([C:7]2[O:8][C:9]3[C:17]([CH2:18][C:19]([OH:21])=[O:20])=[CH:16][CH:15]=[CH:14][C:10]=3[C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.S(=O)(=O)(O)O.[CH2:27](O)[CH3:28]>>[C:1]1([C:7]2[O:8][C:9]3[C:17]([CH2:18][C:19]([O:21][CH2:27][CH3:28])=[O:20])=[CH:16][CH:15]=[CH:14][C:10]=3[C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 14650449HCID 14650449、化合物

生成物 1

HCID 14650456HCID 14650456、化合物

実験手順

[2-(1-Cyclohexenyl)-4-oxo-4H-[1]-benzopyran-8-yl]acetic acid (2.0 g) was dissolved in ethanol (50 ml) and to the solution was added conc. sulfuric acid (0.5 ml). The mixture was heated under reflux for 5 hours. After dilution with water, the mixture was extracted with ethyl acetate and the extract was washed with water, dried (MgSO4) and concentrated under reduced pressure to obtain the title compound as crystals. The crystals were recrystallized from ethyl acetate to obtain prisms, yield 1.34 g (61.0%), m.p. 126°-127° C.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 5 hours
  3. extractionAfter dilution with water, the mixture was extracted with ethyl acetate
  4. washthe extract was washed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-90bb2b0bde91408a8b1e5f90916d1703
出典データセット
uspto-grants-1990_02
特許番号
US04904690

反応ノート

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