Water → HCID 14650455、化合物

HRID 1200194ノート

反応式

HRID 1200194 の反応式
Br[C:2]1([C:8]2[O:9][C:10]3[C:18]([CH2:19][C:20]#[N:21])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[OH2:22]>>[C:2]1([C:8]2[O:9][C:10]3[C:18]([CH2:19][C:20]([NH2:21])=[O:22])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=1

参加物

3

反応物 2

HCID 962WaterHCID 146504442-(1-Bromocyclohexyl)-8-cyanomethyl-4-oxo-4H-[1]-benzopyran

生成物 1

HCID 14650455HCID 14650455、化合物収率 57%

反応条件

温度
120 °C

実験手順

2-(1-Bromocyclohexyl)-8-cyanomethyl-4-oxo-4H-[1]-benzopyran (3.0 g) was added to polyphosphoric acid (120 ml) and the mixture was heated on an oil bath at about 120° C. for 2 hours. After standing overnight, water (about 300 ml) was added to decompose polyphosphoric acid. Crystals deposited were filtered off and recrystallized form the mixed solvent of dichloromethane and methanol to obtain the title compound, yield 57%.

後処理

  1. filtrationCrystals deposited were filtered off
  2. customrecrystallized form the mixed solvent of dichloromethane and methanol

出典と根拠

ORDレコード
ord-e6c1a28b1f2b451da736b2207e9f5ead
出典データセット
uspto-grants-1990_02
特許番号
US04904690

反応ノート

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