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Propargyl alcohol → N-Boc-beta-alanine Propargyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propargyl alcohol | HCID 7859 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-Boc-beta-alanine Propargyl Ester | HCID 11831152 | — |
反応手順
N-Boc-β-alanine (1.91 g, 10.1 mmol) and propargyl alcohol (0.675 g, 12 mmol) were dissolved in EtOAc (25 mL). Dicyclohexyl-carbodiimide (DCC, 2.06 g, 10 mmol) was added to the solution and after 16 h of stirring at room temperature, the reaction mixture was filtered and evaporated to dryness under vacuum. Crude product yield
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727713B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-71ffcbba883a4093b8e3933b35c16e12 |
| 出典メモ | uspto-grants-2010_06 |