関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Tert-Butylbenzenethiol | HCID 75454 | — |
| 反応物 | 2-Chloroethylamine hydrochloride | HCID 9793737 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-(4-t-Butylphenylthio)ethylamine | HCID 13682092 | 74.1% |
反応手順
To a stirring mixture of 4.36 g (38.0 mmol) of 2-chloroethylamine hydrochloride and 12.00 g (87.0 mmol) of K2CO3 in 30 mL of CHCl3 was added 4.82 g (29.0 mmol) of 4-t-butylbenzenethiol. The mixture was stirred at 50° C. in a sealed vial overnight. The mixture was washed three times with distilled water, dried with MgSO4 and filtered. Volatiles were removed in vacuo leaving 4.50 g (74%) of clear oil. 1H NMR (300 MHz, CDCl3): δ=7.32, m, 4H; 2.93, m, 4H; 1.42, broad singlet, 2H; 1.30, s, 9H.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07727926B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-6acfba33d3264d7893baed6626e51411 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
