Ethyl Acetate → HCID 178438818、化合物
反応式
[C:1]([NH2:7])([NH2:6])=[N:2][C:3]([NH2:5])=[S:4].Br[CH:9]1[CH2:14][CH:13]([CH:15]([CH3:17])[CH3:16])[CH2:12][CH2:11][C:10]1=O.C(OCC)(=O)C>C(O)C>[CH:15]([CH:13]1[CH2:14][CH2:9][C:10]2[N:5]=[C:3]([NH:2][C:1]([NH2:7])=[NH:6])[S:4][C:11]=2[CH2:12]1)([CH3:17])[CH3:16]参加物
5
実験手順
2-imino-4-thiobiuret (5 mmol) is added accompanied by stirring to a solution of 2-bromo-4-isopropyl-cyclohexanone (5 mmol) in ethanol (10 ml) and the reaction mixture is then refluxed for 16 hours. After evaporating-off of the solvent ethyl acetate is added to the residue and the precipitated-out product is isolated by filtering off: tR 2.75 min (LC-1, one peak); ESI-MS (+/−): m/z 239.25 [M+H]+/237.24 [M−H]−.
後処理
- temperaturethe reaction mixture is then refluxed for 16 hours
- customthe precipitated-out product is isolated
- filtrationby filtering off
出典と根拠
- ORDレコード
- ord-9498df38666541029593c0303df2705b
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727979B2
反応ノート
読み込み中…