Ethyl Acetate → HCID 178438818、化合物

HRID 12019

反応式

HRID 12019 の反応式
[C:1]([NH2:7])([NH2:6])=[N:2][C:3]([NH2:5])=[S:4].Br[CH:9]1[CH2:14][CH:13]([CH:15]([CH3:17])[CH3:16])[CH2:12][CH2:11][C:10]1=O.C(OCC)(=O)C>C(O)C>[CH:15]([CH:13]1[CH2:14][CH2:9][C:10]2[N:5]=[C:3]([NH:2][C:1]([NH2:7])=[NH:6])[S:4][C:11]=2[CH2:12]1)([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 2724563AmidinothioureaHCID 627080672-Bromo-4-isopropyl-cyclohexanone

生成物 1

HCID 178438818HCID 178438818、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-imino-4-thiobiuret (5 mmol) is added accompanied by stirring to a solution of 2-bromo-4-isopropyl-cyclohexanone (5 mmol) in ethanol (10 ml) and the reaction mixture is then refluxed for 16 hours. After evaporating-off of the solvent ethyl acetate is added to the residue and the precipitated-out product is isolated by filtering off: tR 2.75 min (LC-1, one peak); ESI-MS (+/−): m/z 239.25 [M+H]+/237.24 [M−H]−.

後処理

  1. temperaturethe reaction mixture is then refluxed for 16 hours
  2. customthe precipitated-out product is isolated
  3. filtrationby filtering off

出典と根拠

ORDレコード
ord-9498df38666541029593c0303df2705b
出典データセット
uspto-grants-2010_06
特許番号
US07727979B2

関連ノート

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