1-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone → 2,2,2-Trifluoro-1-[6-(4-hydroxy-4-methyl-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-ethanone

反応式

[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1.[CH3:29][C:30]1([OH:36])[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]1>>[c:2]1([N:33]2[CH2:32][CH2:31][C:30]([CH3:29])([OH:36])[CH2:35][CH2:34]2)[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1

参加物

反応物 2

HCID 115400851-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone

HCID 156491744-Methylpiperidin-4-ol

生成物 1

HCID 115117592,2,2-Trifluoro-1-[6-(4-hydroxy-4-methyl-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-ethanone

出典と根拠

ORDレコード: ord-b42ed635b19e450388625dc1b0775584
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…