N-methyl-2-pyrrolidone → 4-[3-[[5-Chloro-6-(2-methylpyrazol-3-yl)oxy-3-pyridinyl]sulfanyl]phenyl]oxane-4-carboxamide

反応式

[C:32](=[O:33])([O-:34])[O-:35].[CH3:25][n:26]1[n:27][cH:28][cH:29][c:30]1[OH:31].[CH3:38][N:39]1[CH2:40][CH2:41][CH2:42][C:43]1=[O:44].[Cl:1][c:2]1[cH:3][c:4]([S:9][c:10]2[cH:11][c:12]([C:16]3([C:22](=[O:23])[NH2:24])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:13][cH:14][cH:15]2)[cH:5][n:6][c:7]1[Cl:8].[Cs+:36].[Cs+:37]>>[Cl:1][c:2]1[cH:3][c:4]([S:9][c:10]2[cH:11][c:12]([C:16]3([C:22](=[O:23])[NH2:24])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:13][cH:14][cH:15]2)[cH:5][n:6][c:7]1[O:31][c:30]1[n:26]([CH3:25])[n:27][cH:28][cH:29]1