化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 4-(2-Chloro-pyrimidin-4-yloxy)-2,5-dimethyl-phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Amino-2,5-dimethylphenol | HCID 76544 | — |
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(2-Chloro-pyrimidin-4-yloxy)-2,5-dimethyl-phenylamine | HCID 86628974 | — |
反応手順
A solution of 7.55 g (55 mmol) 4-amino-2,5-dimethylphenol and 2.4 g NaOH (2M) in 30 ml water were added dropwise to a solution of 7.45 g (50.0 mmol) of 2,4-dichloropyrimidine in 50 ml of acetone. The reaction mixture was stirred for 20 h at ambient temperature. After concentration in vacuo and addition of 150 ml water the formed precipitate was filtered by suction. Yield 10.6 g (75%) with a purity of 88% log P (pH=2.3)=1.37.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727986B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-610324e3dbed44829fe73fecbe0634b1 |
| 出典メモ | uspto-grants-2010_06 |