Methanol → N'-{4-[2-(3-chloro-2-methyl-phenoxy)-pyrimidin-4-yloxy]-2,5-dimethyl-phenyl}-N-ethyl-N-methyl-formamidine
反応式
[Cl:1][C:2]1[C:3]([CH3:25])=[C:4]([CH:22]=[CH:23][CH:24]=1)[O:5][C:6]1[N:11]=[C:10]([O:12][C:13]2[C:18]([CH3:19])=[CH:17][C:16]([NH2:20])=[C:15]([CH3:21])[CH:14]=2)[CH:9]=[CH:8][N:7]=1.CO.CO[CH:30](OC)[N:31]([CH3:34])[CH2:32][CH3:33]>>[Cl:1][C:2]1[C:3]([CH3:25])=[C:4]([CH:22]=[CH:23][CH:24]=1)[O:5][C:6]1[N:11]=[C:10]([O:12][C:13]2[C:18]([CH3:19])=[CH:17][C:16]([N:20]=[CH:30][N:31]([CH2:32][CH3:33])[CH3:34])=[C:15]([CH3:21])[CH:14]=2)[CH:9]=[CH:8][N:7]=1参加物
4
反応条件
- 温度
- 45 °C
実験手順
To a mixture of 293 mg (0.7 mmol) of 4-[2-(3-chloro-2-methyl-phenoxy)-pyrimidin-4-yloxy]-2,5-dimethyl-phenylamine in 20 ml methanol 182 mg (1.05 mmol) of N-(dimethoxymethyl)-N-methyl-ethanamine (77% pure) was added. The reaction mixture was stirred for 20 hrs at 45° C. The reaction mixture was dried over magnesium sulfate concentrated in vacuo and yielded 290 mg (76%) with a purity of 78%; log P (pH 2.3)=2.08.