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Acetone → 4-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Amino-2,5-dimethylphenol | HCID 76544 | — |
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline | HCID 86628975 | — |
反応手順
A solution of 4.53 g (33 mmol) 4-amino-2,5-dimethylphenol and 1.44 g NaOH (2M) in 30 ml water were added dropwise to a solution of 4.89 g (30.0 mmol) of 2,4-dichloropyrimidine in 50 ml of acetone. The reaction mixture was stirred for 20 h at ambient temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727986B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-a317305e306944ef82b1ad5a3fc53986 |
| 出典メモ | uspto-grants-2010_06 |