Sulfuric Acid → 6-Bromo-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][C:11]([CH3:14])(O)[CH3:12])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[C:11]([CH3:14])([CH3:12])[CH2:10][CH2:9][CH2:8]2参加物
4
実験手順
15.0 g (58.3 mmol) of 5-(3-bromophenyl)-2-methyl-pentan-2-ol (Compound E) was cooled to 0° C. and then 2.8 ml of conc. H2SO4 was added. The mixture was stirred for 2.5 hours, diluted with water (20 ml) and extracted with Et2O (3×40 ml). The combined organic layers were washed with water, sat. aqueous NaHCO3 and brine, dried over MgSO4 and concentrated in vacuo. Purification by kugelrohr distillation gave the title compound as a colorless oil.
後処理
- extractionextracted with Et2O (3×40 ml)
- washThe combined organic layers were washed with water, sat. aqueous NaHCO3 and brine
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
- customPurification
- distillationby kugelrohr distillation
出典と根拠
- ORDレコード
- ord-a7d11788629c4e828999fce2494a1099
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723620
反応ノート
読み込み中…