2-(7-amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N,N-dimethylacetamide → 2-(7-{5-Chloro-4-[3-methyl-4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-2-ylamino}-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N,N-dimethyl-acetamide

反応式

[Cl:21][c:22]1[n:23][cH:24][c:25]([Cl:43])[c:26]([NH:28][c:29]2[cH:30][c:31]([CH3:42])[c:32]([N:35]3[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]3)[cH:33][cH:34]2)[n:27]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:17][c:18]1[O:19][CH3:20])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[N:14]([CH3:15])[CH3:16])[CH2:9][CH2:10]2>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:17][c:18]1[O:19][CH3:20])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[N:14]([CH3:15])[CH3:16])[CH2:9][CH2:10]2)[c:22]1[n:23][cH:24][c:25]([Cl:43])[c:26]([NH:28][c:29]2[cH:30][c:31]([CH3:42])[c:32]([N:35]3[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]3)[cH:33][cH:34]2)[n:27]1