Stannous chloride dihydrate → 3-(2-Aminophenoxy)benzonitrile
反応式
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11])([O-])=O.O.O.Cl[Sn]Cl>CCO>[NH2:1][C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11]参加物
4
実験手順
A solution of 3-(2-nitrophenoxy)benzonitrile (1.21 g, 5 mmol, 1.0 equiv) in 30 mL of EtOH was treated with SnCl2.2H2O (3.38 g, 3 equiv) at reflux for 4 h. The volatile was evaporated and the residue was redissolved in EtOAc, washed with saturated aqueous NaHCO3 and 1N NaOH. The organic layer was dried over MgSO4, filtered and evaporated to give 3-(2-aminophenoxy)benzonitrile (1.04 g, 99%). MS found for Cl3H11N2O (M+H)+: 211.
後処理
- temperatureat reflux for 4 h
- customThe volatile was evaporated
- dissolutionthe residue was redissolved in EtOAc
- washwashed with saturated aqueous NaHCO3 and 1N NaOH
- dry with materialThe organic layer was dried over MgSO4
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-23a25129716941e9a600ead660148e17
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727982B2
反応ノート
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