化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → N-(5-bromopyridin-2-yl)-2-nitrobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2-Nitrobenzoyl chloride | HCID 11875 | — |
| 反応物 | 2-Amino-5-bromopyridine | HCID 70622 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(5-bromopyridin-2-yl)-2-nitrobenzamide | HCID 679218 | 77.9% |
反応手順
A solution of 2-nitrobenzoyl chloride (3.70 g, 20 mmol, 1.0 equiv), 2-amino-5-bromopyridine (3.50 g, 1.0 equiv), pyridine (10 mL) in 25 mL of methylene chloride was stirred overnight. The volatile was evaporated, flash chromatography on silica gel gave N-(5-bromo-2-pyridinyl)-(2-nitro)phenylcarboxamide (5.02 g, 77%). MS found for C12H9BrN3O3 (M+H)+: 322.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727981B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-aff4bb6560f44a6c9e3a0009d8d22301 |
| 出典メモ | uspto-grants-2010_06 |