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Citraconic Anhydrides → N-(5-bromopyridin-2-yl)-methylmaleimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citraconic Anhydrides | HCID 12012 | — |
| 反応物 | 2-Amino-5-bromopyridine | HCID 70622 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-(5-bromopyridin-2-yl)-methylmaleimide | HCID 22596423 | 71% |
反応手順
A mixture of citraconic anhydride (1.00 mL, 11.1 mmol) and 2-amino-5-bromopyridine (1.93 g, 11.2 mmol) in toluene (60 mL) was heated to reflux overnight. The solution was cooled down, filtered. The filtrate was concentrated in vacuo to give a solid (2.10 g, yield: 71%). MS 267 and 269 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727981B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-d06354339c1c4248aa2e70c96f4c2652 |
| 出典メモ | uspto-grants-2010_06 |