2-Methylnicotinic acid → N-(6-chloro-7-ethoxy-9H-beta-carbolin-8-yl)-2-methyl-nicotinamide

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:18])[C:14]=1[O:15][CH2:16][CH3:17])[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[CH3:19][C:20]1[N:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](O)=[O:23]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH:18][C:22](=[O:23])[C:21]3[CH:25]=[CH:26][CH:27]=[N:28][C:20]=3[CH3:19])[C:14]=1[O:15][CH2:16][CH3:17])[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1

参加物

反応物 2

HCID 6433732-Methylnicotinic acid

HCID 671644526-chloro-7-ethoxy-9H-beta-carbolin-8-ylamine

生成物 1

HCID 11440410N-(6-chloro-7-ethoxy-9H-beta-carbolin-8-yl)-2-methyl-nicotinamide収率 40%

実験手順

The desired compound was prepared according to Method A from 6-chloro-7-ethoxy-9H-β-carbolin-8-ylamine and 2-methylnicotinic acid in 40% yield.

出典と根拠

ORDレコード: ord-a246859ab003474d815d88040d024039
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07727985B2

反応ノート

読み込み中…