6-Chloro-9H-beta-carbolin-8-amine → 1,1-Dimethylethyl (5S)-5-[[(6-chloro-9H-pyrido[3,4-b]indol-8-yl)amino]carbonyl]-2,2-dimethyl-4-morpholinecarboxylate

HRID 12224

反応式

HRID 12224 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:15])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[C:16]([O:20][C:21]([N:23]1[CH2:28][C:27]([CH3:30])([CH3:29])[O:26][CH2:25][CH:24]1[C:31](O)=[O:32])=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[C@H:24]([C:31](=[O:32])[NH:15][C:13]2[CH:14]=[C:2]([Cl:1])[CH:3]=[C:4]3[C:12]=2[NH:11][C:10]2[CH:9]=[N:8][CH:7]=[CH:6][C:5]3=2)[CH2:25][O:26][C:27]([CH3:30])([CH3:29])[CH2:28]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

参加物

3

反応物 2

HCID 213627016-Chloro-9H-beta-carbolin-8-amineHCID 50999109HCID 50999109、化合物

生成物 1

HCID 671644951,1-Dimethylethyl (5S)-5-[[(6-chloro-9H-pyrido[3,4-b]indol-8-yl)amino]carbonyl]-2,2-dimethyl-4-morpholinecarboxylate収率 87%

実験手順

The desired compound was prepared according to Method C from 6-chloro-9H-β-carboline-8-ylamine and 6,6-dimethyl-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester in 87% yield.

出典と根拠

ORDレコード
ord-a27e6a4f7bd746fdaef7e84f334dece2
出典データセット
uspto-grants-2010_06
特許番号
US07727985B2

関連ノート

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