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HRID 12247作成日：2026年10月25日

2,6-Dimethylmorpholine → (3S)-N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-4-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-oxoethyl]-6,6-dimethyl-3-morpholinecarboxamide

https://huagongshe.com/reaction/12247

反応式

関与物質

役割名称HCID仕込み量
反応物2,6-DimethylmorpholineHCID 110862—
反応物[5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acidHCID 59337527—
生成物(3S)-N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-4-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-oxoethyl]-6,6-dimethyl-3-morpholinecarboxamideHCID 67165125—

反応手順

The desired compound was prepared using [5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and 2,6-dimethyl morpholine following Method F. Chromatographic purification gave the desired product in 70-80% yield.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07727985B2
出典データセットuspto-grants-2010_06
ORD IDord-497f81d843fd40b38b68639b9989b285
出典メモuspto-grants-2010_06