Bromine → Methyl 2-amino-5-bromo-3-nitrobenzoate

HRID 12253ノート

反応式

HRID 12253 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[NH2:13].[Br:15]Br>C(O)(=O)C>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([Br:15])[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[NH2:13]

参加物

4

反応物 2

HCID 24408BromineHCID 607264Methyl 2-amino-3-nitrobenzoate

生成物 1

HCID 17984898Methyl 2-amino-5-bromo-3-nitrobenzoate収率 87.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 2.23 g (10.4 mmol) of 2-amino-3-nitro-benzoic acid methyl ester in 12 mL of acetic acid was added dropwise over 5 minutes a solution of 0.53 mL (10.4 mmol, 1 eq) of bromine in 2 mL of acetic acid. The mixture was stirred at room temperature for 30 minutes and poured into 100 grams of ice. The precipitated yellow solid was collected by suction filtration and dried to afford 2.50 g (82%) of the title compound as a yellow solid. 1H NMR (CDCl3) δ 3.95 (s, 3H), 8.35 (br s, 2H), 8.6 (d, 1H).

後処理

  1. filtrationThe precipitated yellow solid was collected by suction filtration
  2. customdried

出典と根拠

ORDレコード
ord-becf597f931c48eab6d0ab9385f0ebff
出典データセット
uspto-grants-2010_06
特許番号
US07727992B2

反応ノート

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