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Dimethylformamide → 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 4-Chloro-1,2-diaminobenzene | HCID 7263 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid | HCID 68453325 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide | HCID 86611604 | — |
反応手順
A solution of 110 mg of 6-(2-ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid, 2 ml of DMF and 0.17 ml of triethylamine is mixed with 192 mg of Hatu and stirred at room temperature for 30 minutes. Then 66 mg of 4-chloro-phenylenediamine are added, and the mixture is stirred at room temperature overnight. 5 ml of water are added to the mixture, and the precipitate is briefly stirred and then filtered off with suction and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727989B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-c6db62493a0541ae9904ac2a0c41fb10 |
| 出典メモ | uspto-grants-2010_06 |