6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide → 4-(1H-Benzimidazol-2-yl)-6-chloro-2H-pyridazin-3-one

HRID 12283ノート

反応式

HRID 12283 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[C:12](=[O:18])[NH:13][N:14]=[C:15]([Cl:17])[CH:16]=1)=O>C(O)(=O)C>[NH:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:9]1[C:11]1[C:12](=[O:18])[NH:13][N:14]=[C:15]([Cl:17])[CH:16]=1

参加物

3

反応物 1

HCID 866116096-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-phenyl)amide

生成物 1

HCID 1359787814-(1H-Benzimidazol-2-yl)-6-chloro-2H-pyridazin-3-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 26.4 g of 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-aminophenyl)amide in 500 ml of acetic acid is stirred at 110° C. for 2.5 hours and then the solvent is distilled off. The crude product obtained in this way is employed without further purification.

後処理

  1. distillationthe solvent is distilled off

出典と根拠

ORDレコード
ord-0a5a35357a4242119c12cf0fec91f87f
出典データセット
uspto-grants-2010_06
特許番号
US07727989B2

反応ノート

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