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2,2-Bis(4-fluorophenyl)acetic acid → 2,2-Bis(4-fluorophenyl)-N-methyl-N-[3-(4-(6-fluoro-3-pyridinyl)piperidin-1-yl)propyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2-Bis(4-fluorophenyl)acetic acid | HCID 13511684 | — |
| 反応物 | 3H-spiro(2-benzofuran-1,4'-piperidine) hydrochloride | HCID 22509330 | — |
| 反応物 | 2-Fluoro-5-piperidin-4-ylpyridine | HCID 23092009 | — |
| 反応物 | 2-(3,4-Difluorophenyl)-2-(2-oxo-1-pyrrolidinyl)acetic acid | HCID 23092021 | — |
| 生成物 | 2,2-Bis(4-fluorophenyl)-N-methyl-N-[3-(4-(6-fluoro-3-pyridinyl)piperidin-1-yl)propyl]acetamide | HCID 10480356 | — |
反応手順
Example 9 was repeated except that spiro[isobenzofuran-1(3H), 4′-piperidine] hydrochloride which was used in Example 9-(2) was replaced with 4-(6-fluoro-3-pyridinyl)piperidine, and 2-(3,4-difluorophenyl)-2-(2-oxo-1-pyrrolidinyl)acetic acid which was used in Example 9-(4), with 2,2-bis(4-fluorophenyl)acetic acid, to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07727998B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-2755bc43f82549f695ad2387daaac869 |
| 出典メモ | uspto-grants-2010_06 |