Acetone → 7',8'-dimethyl-1'-(quinolin-2-ylmethyl)-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-quinolin]-6'-ol

反応式

[CH3:1][c:2]1[c:3]([OH:16])[cH:4][c:5]2[c:6]([c:7]1[CH3:8])[NH:9][CH2:10][CH2:11][C:12]21[CH2:13][CH2:14][CH2:15]1.[CH3:37][C:38](=[O:39])[CH3:40].[Cl:17][CH2:18][c:19]1[n:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[cH:27][cH:28]1.[I-:36].[K+:29].[K+:30].[Na+:35].[O-:31][C:32]([O-:33])=[O:34]>>[CH3:1][c:2]1[c:3]([OH:16])[cH:4][c:5]2[c:6]([c:7]1[CH3:8])[N:9]([CH2:18][c:19]1[n:20][c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]3[cH:27][cH:28]1)[CH2:10][CH2:11][C:12]21[CH2:13][CH2:14][CH2:15]1