Dimethylformamide → 4-chloro-8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one

反応式

[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8]([CH3:9])=[O:10])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][c:19]([F:22])[cH:20][cH:21]1)[c:12](=[O:15])[cH:13][cH:14]2.[Cl:30][CH2:31][Cl:32].[NH2:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][c:19]([F:22])[cH:20][cH:21]1)[c:12](=[O:15])[cH:13][cH:14]2