2-(Morpholin-4-yl)propan-1-amine → 8-Indan-5-yl-2-(2-morpholin-4-yl-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

関与物質

反応手順

Using the procedure outlined in Example 1(Step F) the title compound was prepared from 2-morpholin-4-yl-propylamine (5.3 μL, 0.036 mmol) and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(Step E), 15 mg, 0.036 mmol). 17.2 mg of 8-indan-5-yl-2-(2-morpholin-4-yl-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.26 (s, 1H), 8.46 (s, 1H), 7.02-7.40 (m, 3H), 6.64 (br, 1H), 4.35 (q, 2H), 3.71 (m, 4H), 3.22 (m, 2H), 2.98 (m, 4H), 2.38 (m, 6H), 2.17 (m, 2H), 1.67 (m, 2H), 1.37 (t, 3H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C26H31N5O4: 478.24 (M+H). Found: 478.4.

情報源と証拠