2-(Morpholin-4-yl)propan-1-amine → 8-Indan-5-yl-2-(2-morpholin-4-yl-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12337

反応式

HRID 12337 の反応式
[N:1]1([CH:7]([CH3:10])[CH2:8][NH2:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:11]([O:13][C:14]([C:16]1[C:17](=[O:39])[C:18]2[CH:23]=[N:22][C:21](S(C)(=O)=O)=[N:20][C:19]=2[N:28]([C:30]2[CH:31]=[C:32]3[C:36](=[CH:37][CH:38]=2)[CH2:35][CH2:34][CH2:33]3)[CH:29]=1)=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1[C:17](=[O:39])[C:18]2[CH:23]=[N:22][C:21]([NH:9][CH2:8][CH:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[CH3:10])=[N:20][C:19]=2[N:28]([C:30]2[CH:31]=[C:32]3[C:36](=[CH:37][CH:38]=2)[CH2:35][CH2:34][CH2:33]3)[CH:29]=1)=[O:15])[CH3:12]

参加物

3

反応物 2

HCID 166414542-(Morpholin-4-yl)propan-1-amineHCID 252229828-Indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

生成物 1

HCID 685835178-Indan-5-yl-2-(2-morpholin-4-yl-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

実験手順

Using the procedure outlined in Example 1(Step F) the title compound was prepared from 2-morpholin-4-yl-propylamine (5.3 μL, 0.036 mmol) and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(Step E), 15 mg, 0.036 mmol). 17.2 mg of 8-indan-5-yl-2-(2-morpholin-4-yl-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.26 (s, 1H), 8.46 (s, 1H), 7.02-7.40 (m, 3H), 6.64 (br, 1H), 4.35 (q, 2H), 3.71 (m, 4H), 3.22 (m, 2H), 2.98 (m, 4H), 2.38 (m, 6H), 2.17 (m, 2H), 1.67 (m, 2H), 1.37 (t, 3H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C26H31N5O4: 478.24 (M+H). Found: 478.4.

出典と根拠

ORDレコード
ord-221d7370a8be4b47a16e7531e653c480
出典データセット
uspto-grants-2010_06
特許番号
US07728003B2

関連ノート

読み込み中…