N,N-Dimethyl-1,3-propanediamine → 2-(3-Dimethylamino-propylamino)-8-indan-5-yl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12338

反応式

HRID 12338 の反応式
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].[CH2:8]([O:10][C:11]([C:13]1[C:14](=[O:36])[C:15]2[CH:20]=[N:19][C:18](S(C)(=O)=O)=[N:17][C:16]=2[N:25]([C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[CH2:32][CH2:31][CH2:30]3)[CH:26]=1)=[O:12])[CH3:9]>>[CH2:8]([O:10][C:11]([C:13]1[C:14](=[O:36])[C:15]2[CH:20]=[N:19][C:18]([NH:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:7])[CH3:1])=[N:17][C:16]=2[N:25]([C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[CH2:32][CH2:31][CH2:30]3)[CH:26]=1)=[O:12])[CH3:9]

参加物

3

反応物 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 252229828-Indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

生成物 1

HCID 685835872-(3-Dimethylamino-propylamino)-8-indan-5-yl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

実験手順

Using the procedure outlined in Example 1(Step F) the title compound was prepared from N1,N1-dimethyl-propane-1,3-diamine (4.6 μL, 0.036 mmol) and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(Step E), 15 mg, 0.036 mmol). 9.7 mg of 2-(3-dimethylamino-propylamino)-8-indan-5-yl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.23 (s, 1H), 8.46 (s, 1H), 7.34 (d, 1H), 7.23 (s, 1H), 7.13 (d, 1H), 6.77 (br, 1H), (m, 2H), 2.99 (m, 4H), 2.19 (m, 10H), 1.60 (m, 2H), 1.37 (t, 3H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C24H29N5O3: 436.23 (M+H). Found: 436.4.

出典と根拠

ORDレコード
ord-c76918262cac4fbda4c8bbbb28c023b4
出典データセット
uspto-grants-2010_06
特許番号
US07728003B2

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