1-Pyrrolidinepropanamine → HCID 68583389、化合物

HRID 12341

反応式

HRID 12341 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:10]([O:12][C:13]([C:15]1[C:16](=[O:38])[C:17]2[CH:22]=[N:21][C:20](S(C)(=O)=O)=[N:19][C:18]=2[N:27]([C:29]2[CH:30]=[C:31]3[C:35](=[CH:36][CH:37]=2)[CH2:34][CH2:33][CH2:32]3)[CH:28]=1)=[O:14])[CH3:11]>>[CH2:10]([O:12][C:13]([C:15]1[C:16](=[O:38])[C:17]2[CH:22]=[N:21][C:20]([NH:9][CH2:8][CH2:7][CH2:6][N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[N:19][C:18]=2[N:27]([C:29]2[CH:30]=[C:31]3[C:35](=[CH:36][CH:37]=2)[CH2:34][CH2:33][CH2:32]3)[CH:28]=1)=[O:14])[CH3:11]

参加物

3

反応物 2

HCID 316701-PyrrolidinepropanamineHCID 252229828-Indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

生成物 1

HCID 68583389HCID 68583389、化合物

実験手順

Using the procedure described in Example 1 Step F, the title compound was prepared from 3-pyrrolidin-1-yl-propylamine and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(Step E), 10 mg, 0.022 mmol). 7 mg of 8-Indan-5-yl-5-oxo-2-(3-pyrrolidin-1-yl-propylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.24 (s, 1H), 8.76 (s, 1H), 7.30 (d, J=7.7 Hz, 1H), 7.21 (s, 1H), 7.14 (d, J=7.7 Hz, 1H), 5.72 (br, 1H), 4.36 (q, J=7.1 Hz, 2H), 3.27 (m, 2H), 2.98 (m, 4H), 2.50 (m, 6H), 2.17 (m, 2H), 1.80 (m, 4H), 1.68 (m, 2H), 1.38 (t, J=7.1 Hz, 3H).

出典と根拠

ORDレコード
ord-1919b9c11bfd4ee3b0e8b1354be000fd
出典データセット
uspto-grants-2010_06
特許番号
US07728003B2

関連ノート

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