関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 3-chloropropionate | HCID 69341 | — |
| 触媒 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 生成物 | Ethyl 3-(cyclohexylamino)propanoate | HCID 243063 | 72.3% |
反応手順
Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728003B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-66ca2717a0e24c2293f8cef297ade30e |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
