N,N-Dimethyl-1,3-propanediamine → 8-Cyclohexyl-2-(3-dimethylamino-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12354

反応式

HRID 12354 の反応式
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].[CH2:8]([O:10][C:11]([C:13]1[C:14](=[O:33])[C:15]2[CH:20]=[N:19][C:18](S(C)(=O)=O)=[N:17][C:16]=2[N:25]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH:26]=1)=[O:12])[CH3:9]>>[CH2:8]([O:10][C:11]([C:13]1[C:14](=[O:33])[C:15]2[CH:20]=[N:19][C:18]([NH:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:7])[CH3:1])=[N:17][C:16]=2[N:25]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH:26]=1)=[O:12])[CH3:9]

参加物

3

反応物 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 252234828-Cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

生成物 1

HCID 685830828-Cyclohexyl-2-(3-dimethylamino-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

実験手順

Using the procedure outlined in Example 28 Step F, the title compound was prepared from N′,N′-dimethyl-propane-1,3-diamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (Example 35 Step E, 20 mg, 0.05 mmol). 8-Cyclohexyl-2-(3-dimethylamino-propylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (17 mg, 85%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C21H31N5O3: 402.24 (M+H). Found: 402.2.

出典と根拠

ORDレコード
ord-eb360499e0074ed69a9c2ddd2a649271
出典データセット
uspto-grants-2010_06
特許番号
US07728003B2

関連ノート

読み込み中…