1-Pyrrolidineethanamine → 8-Cyclohexyl-5-oxo-2-(2-pyrrolidin-1-yl-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12360

反応式

HRID 12360 の反応式
[N:1]1([CH2:6][CH2:7][NH2:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]([O:11][C:12]([C:14]1[C:15](=[O:34])[C:16]2[CH:21]=[N:20][C:19](S(C)(=O)=O)=[N:18][C:17]=2[N:26]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH:27]=1)=[O:13])[CH3:10]>>[CH2:9]([O:11][C:12]([C:14]1[C:15](=[O:34])[C:16]2[CH:21]=[N:20][C:19]([NH:8][CH2:7][CH2:6][N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[N:18][C:17]=2[N:26]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH:27]=1)=[O:13])[CH3:10]

参加物

3

反応物 2

HCID 13441-PyrrolidineethanamineHCID 252234828-Cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

生成物 1

HCID 685835138-Cyclohexyl-5-oxo-2-(2-pyrrolidin-1-yl-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

実験手順

Using the procedure outlined in Example 28 Step F, the title compound was prepared from 2-pyrrolidin-1-yl-ethylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (25 mg, 0.07 mmol). 8-Cyclohexyl-5-oxo-2-(2-pyrrolidin-1-yl-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (18 mg, 80%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C22H31N5O3: 414.24 (M+H). Found: 414.3.

出典と根拠

ORDレコード
ord-0325c45435ff4ca4a98f12cfd7a32f52
出典データセット
uspto-grants-2010_06
特許番号
US07728003B2

関連ノート

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