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Benzoyl isothiocyanate → 1-benzoyl-3-(2-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)phenyl)thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl isothiocyanate | HCID 68284 | — |
| 反応物 | 2-(4,4-Dimethyl-3,4-dihydroquinolin-1(2H)-yl)aniline | HCID 59337707 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-benzoyl-3-(2-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)phenyl)thiourea | HCID 59337689 | — |
反応手順
1d (65.4 mg, mmol) and benzoyl isothiocyanate (60 mg) were heated at refluxing CH2Cl2 for 2 h. After cooling, the solvent was evaporated. The resulting crude 1e was dried over vacuum and used directly in the next step: LC-MS ESI, 416.3 (M+H) (10-90% MeOH in H2O with 0.1% TFA in a 4 min run, tR=4.49 min).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728008B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f29cdedad1cb4ee98680c27ced2d0799 |
| 出典メモ | uspto-grants-2010_06 |