Acetic Anhydride → 1-Acetylindolin-2-one

HRID 12385

反応式

HRID 12385 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])(=[O:13])[CH3:12]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 321710Oxindole

生成物 1

HCID 3237191-Acetylindolin-2-one収率 93.7%

実験手順

Indoline-2-one (6.65 g, 50 mmol) and acetic anhydride (9 mL) were heated at reflux for 15 h. After cooling, the product was filtered and rinsed with Et2O to give 2a as solids after vacuum drying (8.2 g, yield: 93.7 %).

後処理

  1. temperatureat reflux for 15 h
  2. temperatureAfter cooling
  3. filtrationthe product was filtered
  4. washrinsed with Et2O

出典と根拠

ORDレコード
ord-a7734ec7f6ab472a91dc21117afbdc06
出典データセット
uspto-grants-2010_06
特許番号
US07728008B2

関連ノート

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