関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (2-(4-Fluorophenoxy)-ethyl)-carbamic acid tert-butyl ester | HCID 23134036 | — |
反応手順
To the crude product (700 mg) of t-butyl 2-bromoethylcarbamate obtained in Step 1 were added 4-fluorophenol (875 mg), potassium carbonate (1.08 g) and DMF (7 ml), and the mixture was stirred overnight at 90° C. The solvent was evaporated, and the mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated. The obtained crude product was purified by silica gel chromatography (ethyl acetate-hexane) to give t-butyl 2-(4-fluorophenoxy)ethylcarbamate (390 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728005B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-1f2d8b6dfd7647258a6c9672414d151f |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
