Triethylamine → (S)-Methanesulphonic acid 2-Boc-aminopropyl ester
反応式
[OH:1][CH2:2][C@@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4].[CH3:13][S:14](Cl)(=[O:16])=[O:15].C(N(CC)CC)C>ClCCl>[CH3:13][S:14]([O:1][CH2:2][C@@H:3]([NH:5][C:6]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:12])[CH3:4])(=[O:16])=[O:15]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To the compound (5.9 g) obtained in Step 1 were added methanesulfonyl chloride (3.1 ml), triethylamine (9.0 ml) and dichloromethane (150 ml), and the mixture was stirred at 0° C. for 2 hrs. The mixture was diluted with dichloromethane and, after washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.
後処理
- washafter washing with water
- dry with materialthe organic layer was dried over anhydrous magnesium sulfate
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-6f5c4f28190c47c0b1aa9429d8e223c6
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728005B2
反応ノート
読み込み中…