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Ethanol → 8-Amino-5-nitroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Nitroisoquinoline | HCID 69085 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 8-Amino-5-nitroisoquinoline | HCID 11084625 | 57.5% |
反応手順
To 5-nitroisoquinoline (2.0 g) were added hydroxylamine hydrochloride (5.0 g) and ethanol (120 ml). A solution of sodium hydroxide (10 g) in methanol (65 ml) was slowly added at 50° C. over 90 min. The reaction mixture was poured into ice water (700 g) and the resulting precipitate was collected by filtration. The residue was washed with ethanol and dried under reduced pressure to give 8-amino-5-nitroisoquinoline (1.25 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728005B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-5e9a210e943d4c09b800007a646d13db |
| 出典メモ | uspto-grants-2010_06 |