Ethanol → 8-Amino-5-nitroisoquinoline

HRID 12413

反応式

HRID 12413 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-:3])=[O:2].Cl.[NH2:15]O.C(O)C.[OH-].[Na+]>CO>[NH2:15][C:11]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[C:5]2[C:10]=1[CH:9]=[N:8][CH:7]=[CH:6]2

参加物

6

反応物 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 690855-NitroisoquinolineHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 110846258-Amino-5-nitroisoquinoline収率 57.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 5-nitroisoquinoline (2.0 g) were added hydroxylamine hydrochloride (5.0 g) and ethanol (120 ml). A solution of sodium hydroxide (10 g) in methanol (65 ml) was slowly added at 50° C. over 90 min. The reaction mixture was poured into ice water (700 g) and the resulting precipitate was collected by filtration. The residue was washed with ethanol and dried under reduced pressure to give 8-amino-5-nitroisoquinoline (1.25 g).

後処理

  1. filtrationthe resulting precipitate was collected by filtration
  2. washThe residue was washed with ethanol
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-5e9a210e943d4c09b800007a646d13db
出典データセット
uspto-grants-2010_06
特許番号
US07728005B2

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