2-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine → 3-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine

HRID 1241307ノート

反応式

HRID 1241307 の反応式
[CH3:1][O:2][C:3]([CH:5]([O:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][CH:11]=[CH:10][N:9]=1)[CH3:6])=[O:4]>[Pt]=O.C(O)C>[NH2:14][C:13]1[C:8]([O:7][CH:5]([C:3]([O:2][CH3:1])=[O:4])[CH3:6])=[N:9][CH:10]=[CH:11][CH:12]=1

参加物

4

反応物 1

HCID 219335712-{1-(Methoxycarbonyl)ethoxy}-3-nitropyridine

生成物 1

HCID 219335303-Amino-2-{1-(methoxycarbonyl)ethoxy}pyridine収率 78.7%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1.7 g of 2-{1-(methoxycarbonyl)ethoxy}-3-nitropyridine, 102 mg of platinum oxide, and 7.5 ml of ethanol was stirred at room temperature under an atmosphere of hydrogen gas for 3.5 hours. The gas in the atmosphere on the reaction system was replaced with nitrogen gas, and the reaction mixture was filtered through Celite. The filtrate was concentrated. The residue was subjected to silica gel column chromatography to give 1.16 g of 3-amino-2-{1-(methoxycarbonyl)ethoxy}pyridine.

後処理

  1. filtrationthe reaction mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-95bb3367e3eb4dfa9f8e38097c82f600
出典データセット
uspto-grants-2006_10
特許番号
US07115544B2

反応ノート

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