4-Chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline → HCID 21936057、化合物
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Br:25][C:26]1[C:31]([NH2:32])=[C:30]2[O:33][CH2:34][O:35][C:29]2=[CH:28][CH:27]=1>>[Br:25][C:26]1[C:31]([NH:32][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[C:30]2[O:33][CH2:34][O:35][C:29]2=[CH:28][CH:27]=1参加物
3
実験手順
Using an analogous procedure to that described in Example 15, 4-chloro-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline was reacted with 6-bromo-2,3-Methylenedioxyaniline to give the title compound as a solid; NMR Spectrum: DMSOd6 and CF3CO2D) 2.3 (m, 2H), 2.95 (s, 3H), 3.2–3.9 (br s, 8H), 3.4 (m, 2H), 4.0 (s, 3H), 4.35 (m, 2H), 6.15 (s, 2H), 7.05 (d, 1H), 7.3 (d, 1H), 7.4 (s, 1H), 8.15 (s, 1H), 8.9 (s, 1H); Mass Spectrum: M+H+ 530 and 532; Elemental Analysis: Found C, 54.25; H, 5.54; N, 12.8. C24H28BrN5O4 requires C, 54.35; H, 5.32; N, 13.2%.
出典と根拠
- ORDレコード
- ord-facc6c9564654b8c9fe2828aac488eee
- 出典データセット
- uspto-grants-2006_10