Acetic Acid Mixture with Hydrobromic Acid → 3-(3-methylphenoxy)-N1-(2-nitrophenyl)-1,2-propanediamine hydrobromide

HRID 12417

反応式

HRID 12417 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[O:5][CH2:6][CH:7]([NH:19]C(=O)OCC1C=CC=CC=1)[CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17].[BrH:33].C(O)(=O)C>ClCCl>[BrH:33].[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[O:5][CH2:6][CH:7]([NH2:19])[CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17]

参加物

4

反応物 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 68698461Benzyl 2-(3-methylphenoxy)-1-[(2-nitroanilino)methyl]ethylcarbamate

生成物 1

HCID 686969873-(3-methylphenoxy)-N1-(2-nitrophenyl)-1,2-propanediamine hydrobromide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To the compound obtained in Step 2 were added 30% hydrobromide/acetic acid (1 ml) and dichloromethane (2 ml), and the mixture was stirred at 0° C. for 2 hrs. The mixture was diluted with dichloromethane, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to give the title compound as a crude product.

後処理

  1. washwashed with saturated aqueous sodium hydrogen carbonate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-3d3cb8533ec6479193672c26c1ce3bd8
出典データセット
uspto-grants-2010_06
特許番号
US07728005B2

関連ノート

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