Acetic Anhydride → N-(4-Chloro-3-nitrophenyl)acetamide

HRID 1242044

反応式

HRID 1242044 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 124774-Chloro-3-nitroaniline

生成物 1

HCID 79672N-(4-Chloro-3-nitrophenyl)acetamide収率 101.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 4-chloro-3-nitroaniline (51.8 g, 0.36 mol) in anhydrous DCM (300 mL) was added dropwise acetic anhydride (45 mL, 0.48 mol) at room temperature, and the resulting solution was stirred at room temperature for 3 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitates were collected by filtration, washed thoroughly with Et2O, and dried under high vacuum to give 4′-chloro-3′-nitroacetanilide (78.7 g, 100%).

後処理

  1. customThe solvent was removed in vacuo, and Et2O
  2. additionwas added to the residue
  3. filtrationThe precipitates were collected by filtration
  4. washwashed thoroughly with Et2O
  5. customdried under high vacuum

出典と根拠

ORDレコード
ord-74bef879f0de46b89e8eae68ef284cc5
出典データセット
uspto-grants-2006_10
特許番号
US07115640B2

関連ノート

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