Hydrochloric Acid → HCID 21936741、化合物

HRID 1242072ノート

反応式

HRID 1242072 の反応式
C(OC([N:8]1[CH2:17][CH2:16][C:11]2([O:15][CH2:14][CH2:13][O:12]2)[CH2:10][CH:9]1[CH2:18][N:19]1[C:27](=[O:28])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]1=[O:29])=O)(C)(C)C.[ClH:30]>ClCCl.C(OCC)C>[ClH:30].[O:12]1[C:11]2([CH2:16][CH2:17][NH:8][CH:9]([CH2:18][N:19]3[C:20](=[O:29])[C:21]4[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:27]3=[O:28])[CH2:10]2)[O:15][CH2:14][CH2:13]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 69585793HCID 69585793、化合物

生成物 1

HCID 21936741HCID 21936741、化合物収率 90%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

To the above 7-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (1.1 g, 2.7 mmol) dissolved in dichloromethane (6 ml) was added 1.0 N hydrogen chloride in diethyl ether (50 ml) and the solution kept at ambient temperature for 62 h. The precipitate was filtered off and washed with diethyl ether and dried with nitrogen which afforded 0.83 g (90%) of 2-(1,4-dioxa-8-aza-spiro[4.5]dec-7-ylmethyl)-isoindole-1,3-dione hydrochloride as a solid.

後処理

  1. filtrationThe precipitate was filtered off
  2. washwashed with diethyl ether
  3. customdried with nitrogen which

出典と根拠

ORDレコード
ord-cfc5034c04284363a8300efda199ffa4
出典データセット
uspto-grants-2006_10
特許番号
US07115624B1

反応ノート

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