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Pyridine → Methyl 4-(2-oxobutyl)-3-nitrobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Propionyl chloride | HCID 62324 | — |
| 反応物 | (E)-Methyl 4-(2-(dimethylamino)vinyl)-3-nitrobenzoate | HCID 894337 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 4-(2-oxobutyl)-3-nitrobenzoate | HCID 21938235 | — |
反応手順
According to the method of Production Example 1, a mixed solution of methyl E-4-(2-dimethylaminovinyl)-3-nitrobenzoate (6.30 g), pyridine (3.2 ml), propionyl chloride (3.26 g) and methylene chloride (60 ml) is heated under reflux for 11 hours, and then heated under reflux with 1,4-dioxane in water for 16 hours to obtain methyl 4-(2-oxobutyl)-3-nitrobenzoate (5.63 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07115647B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-44241f6f06f8418bbcc629a864c0f360 |
| 出典メモ | uspto-grants-2006_10 |