2-Bromo-4-chloro-6-fluoroaniline → N,N-dimethyl-5-ethyl-2-(2'-bromo-4'-chloro-6'-fluoroanilino)phenylacetamide

反応式

[CH3:1][N:2]([CH3:15])[C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[C:9]([CH2:11][CH3:12])[CH:8]=[CH:7][C:6]=1I.[Br:16][C:17]1[CH:23]=[C:22]([Cl:24])[CH:21]=[C:20]([F:25])[C:18]=1[NH2:19]>>[CH3:1][N:2]([CH3:15])[C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[C:9]([CH2:11][CH3:12])[CH:8]=[CH:7][C:6]=1[NH:19][C:18]1[C:20]([F:25])=[CH:21][C:22]([Cl:24])=[CH:23][C:17]=1[Br:16]

参加物

反応物 2

HCID 27362222-Bromo-4-chloro-6-fluoroaniline

HCID 21938643N,N-dimethyl-5-ethyl-2-iodophenylacetamide

生成物 1

HCID 86584270N,N-dimethyl-5-ethyl-2-(2'-bromo-4'-chloro-6'-fluoroanilino)phenylacetamide

実験手順

Ullmann condensation of N,N-dimethyl-5-ethyl-2-iodo-phenylacetamide with 2-bromo-4-chloro-6-fluoroaniline according to the procedure described in Example 1 yields N,N-dimethyl-5-ethyl-2-(2′-bromo-4′-chloro-6′-fluoroanilino)phenylacetamide.

出典と根拠

ORDレコード: ord-68ecbda0b3254006aa4bdee778e4a2d2
出典データセット: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07115662B2

反応ノート

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