Aluminium lithium hydride → [2-Cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-yl]-methanol
反応式
C([O:3][C:4](=O)[C:5]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][C:8]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)=[N:7][C:6]=1[CH:26]1[CH2:28][CH2:27]1)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH:26]1([C:6]2[C:5]([CH2:4][OH:3])=[C:10]([C:11]([F:12])([F:14])[F:13])[CH:9]=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:23])[F:24])=[CH:17][CH:16]=3)[N:7]=2)[CH2:28][CH2:27]1参加物
3
実験手順
In analogy to the procedure described in example 43D], 2-cyclopropyl-6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid ethyl ester was treated with lithium aluminium hydride to give the title compound as colorless crystals.
出典と根拠
- ORDレコード
- ord-d604906e43ba4635b236da57d0db06c3
- 出典データセット
- uspto-grants-2006_10
- DOI